Fountain Of Youth History
My optimism for prolonging human life in good health until a few notches in 2009, when test results came out of rapamycin. This was an important event in the fight against aging research could have implications for longevity and rejuvenation.
Rapamycin is the first drug known to prolong life in healthy mice. The mice are genetically similar to humans, then what is good for the mouse can be good for the man (and woman). This study is the result of chance. Two fortuitous events lead to a discovery that could change the face of old age.
Back in the 1980s, Dr. Z. Dave Sharp of the University of Texas, San Antonio heard about an experiment conducted Switzerland, not related to aging, using rapamycin. I had a hunch that this immunosuppressive drug May effort to prolong life, but seemed to affect cell growth in laboratory animals, much like calorie restriction, already proven to prolong life. Was an idea that has been around for many years, nobody was interested.
Almost 20 years after a conversation with a colleague gave him the insight of experience and void. It was 2004 and the intervention of the National Institute of Testing Program on Aging (NIA), was newly formed. Founded by Huber Warner, he has done. "I saw a pile of papers from beneficiaries of the NIA to slow aging and prolong life, but rarely backed up and given credibility by evidence. Huber realized that a specialized program that is needed for more than a laboratory to confirm whether an intervention works. He suggested the idea at the NIA, which led to the intervention Testing Program.
ITP In general, studies based on selected treatments which are readily available at reasonable prices in the food supply of mice. The research was in three laboratories chosen by ITP achieve experiments with mice, University of Michigan, the Jackson Laboratory in Maine and the University of Texas Health Science Center San Antonio – the same university where he is based Dave Sharp.
It was this program that Dave has taken the ideas from concept to reality, efficiency and credibility. Dave talked about his idea of Randy Strong, the head of the Laboratory of San Antonio and Randy liked it. Dave encouraged to develop a testing proposal. It was approved in 2005.
Things are a little complicated after. Mice that were ready to go, but initial tests showed that rapamycin in mice food have lost their power. Randy Fast and Furious has worked with Purina to find a solution, and he did. Rapamycin is encapsulated to preserve their strength and be released in the intestine of mice. This was a mode of delivery of the novel.
To This time, the mice were aged approximately 600 days – the equivalent of 60 years in human age. The researchers had to decide whether must continue, it was too late to replace about 2,000 genetically similar mice who were ready to go. Fortunately did.
The results were beyond what I could expect. Rapamycin delayed the death of the longest life span of male mice for 101 days and longer mouse experienced by 151 days. Who is like 13 years man! Or, if one takes into account the remaining life average when treatment began, or increased 38% in female mice and 28% in males.
How rapamycin remains uncertain. It can affect the performance of cells resulting from delayed aging and maintaining good health. The results indicate that the drug does not prevent disease, the mice died of causes diverse, but they indicate that age has been reduced. The mice remained healthy and cancer free longer any hope normal life.
Test Action Program tests were performed with aspirin, green tea extract and other interventions. The results of rapamycin is the first great triumph of a study of ITP, with strong results in the rejuvenation and extended life among male and female mice.
It remains to be seen what impact this will have on humans, but the idea that a drug – an immunosuppressant used in transplant patients, found in soil samples from Easter Island 40 years ago – could give us better health longer and are good news!
Fountain Of Youth’s History Of World
